Cristina Almenglo
Medical Scientist
Sanlúcar
Summary
Genetic Analyst and Molecular Biologist with extensive expertise in somatic genetic analysis, oncology, and molecular diagnostics, seeking to leverage my background in a commercial setting within the pharmaceutical or biotech industry. Demonstrated ability to apply advanced genetic techniques, including Next-Generation Sequencing (NGS) and Sanger sequencing, to the analysis and categorization of oncogenic variants. Proven track record in designing and executing research projects, managing biobank operations, and delivering precise molecular reports for clinical application. Adept at translating complex scientific insights into actionable clinical data, with a strong focus on personalized medicine and supporting therapeutic decision-making processes.
Overview
6
6
years of professional experience
13
13
years of post-secondary education
1
1
Certification
Work History
Genetic Analyst - Clinical Laboratory Assistant
Anatomical Pathology Laboratory
8 2022 - Current
- Full-time clinical role focused on the preparation of libraries and safety analysis for the TruSight Oncology 500 panel, performing somatic genetic analyses
- Conducted molecular analyses using the Oncomine Comprehensive Assay (Thermo Fisher Scientific), contributing to clinical trial programs by applying NGS multi-biomarker technology to characterize tumors
- Executed and interpreted Sanger sequencing in key regions of genes such as POLE, TERT, CTNNB1, PDGFRA, KIT, IDH1/2, among others, for clinical genetic profiling
- Prepared comprehensive molecular reports that included identification, interpretation, and categorization of oncogenic variants, aimed at guiding personalized treatment options for multiple pathologies, such as colorectal, pancreatic, cholangiocarcinoma, NSCLC, adenocystic carcinoma, and GIST
- Collaborated with oncologists and clinical researchers to ensure the accurate application of molecular insights in patient treatment.
Postdoctoral Associate
Department of Environmental Health Sciences, Brain, Behavior and Environment Laboratory
08.2022 - 08.2023
- Led experimental setups involving primary culture of microglia, behavioral studies, and advanced biochemical techniques (Western blotting, immunocytochemistry)
- Applied confocal microscopy and flow cytometry to cellular analysis, reinforcing interdisciplinary approaches for understanding disease processes.
Researcher Specialist I
Center of Health Research Institute of Santiago de Compostela (IDIS), Inflammation-Cardiology Area
01.2019 - 06.2022
- Managed the collection, processing, and biobanking of patient samples for major cardiology research studies, including REDISCORIII and FAISCA projects
- Contributed to clinical trials assessing the effects of edoxaban, financed by Daiichi Sankyo, and worked on tissue culture, angiogenesis assays, real-time PCR, and animal models of myocardial infarction
- Responsible for the development and maintenance of research protocols, ensuring compliance with quality standards for reproducibility in clinical studies.
Education
Ph.D. in Molecular Medicine -
University of Santiago de Compostela
03.2017 - 06.2022
M.Sc. in Clinical Trials - undefined
University of Sevilla
Current - 12.2024
M.Sc. in Microbiology Research - undefined
University of Granada
09.2010 - 06.2011
B.Sc. in Molecular Biology - undefined
University of Granada
09.2002 - 06.2009
Skills
Genetic Analysis & Molecular Diagnostics: Expertise in NGS (TruSight Oncology 500, Oncomine Comprehensive Assay) and Sanger sequencing for the identification, interpretation, and categorization of oncogenic variants in somatic mutations
Oncology & Personalized Medicine: Specialized in multiple oncology indications, including colorectal cancer, pancreatic cancer, non-small cell lung cancer (NSCLC), cholangiocarcinoma, and gastrointestinal stromal tumors (GIST) Experience in producing detailed molecular reports that support personalized treatment strategies
Clinical & Research Expertise: Proven experience in both academic and clinical research environments, including clinical trials, with a focus on translating research findings into clinical application
Cross-functional Collaboration: Experienced in working within multidisciplinary teams, bridging the gap between research, clinical needs, and commercial goals Strong communication skills, adaptable to corporate environments, and client-focused
MS Excel
Documentation And Reporting
Report Preparation
Excel proficiency
Root Cause Analysis
Team Collaboration and Leadership
Analytical Thinking
Additional Qualifications
- Clinical Trials & Laboratory Certifications: Certified in Good Clinical Practice (GCP) and various lab-specific training programs.
- Animal Experimentation & Ethics: Experience in animal models and certified by CITI Program and FIU IACUC.
Technicalskills
NGS (TruSight Oncology 500, Oncomine Assay), Sanger Sequencing, Real-Time PCR, SDS-PAGE, Immunohistochemistry, Western Blotting, Genetic engineering, Plasmid construction, Transfection, Immunoprecipitation, siRNA/shRNA preparation, Stable cell line generation, Microsoft Excel, GraphPad Prism, SPSS, FlowJo software, Confocal microscopy, Fluorescence microscopy, ImageJ
Relevantprojectsachievements
- Clinical Trial Contributions: Assisted in trials involving edoxaban with a focus on evaluating myocardial and endothelial outcomes, funded by Daiichi Sankyo.
- Cardiology Research: Conducted in-depth analyses of inflammatory markers in patients with atrial fibrillation and/or heart failure, providing insights into novel therapeutic approaches.
Publicationsconferences
Extensive publication record in leading journals such as European Journal of Pharmacology, Journal of Cardiovascular Translational Research, and Journal of Molecular Medicine., Presented at major international conferences, including the World Congress of Cardiology and Spanish Society of Cardiology events.
References
Available upon request.
Languages
Spanish
English
Personal Qualities
- Adaptability & Proactivity: Strong ability to adapt to dynamic environments, with an emphasis on achieving business-oriented goals in a scientific context.
- Communication & Team Collaboration: Effective in both team settings and independent work. Capable of translating complex scientific data into actionable insights for stakeholders.
Accomplishments
Ph.D. in Molecular Medicine with honors, specializing in oncology and precision medicine. Developed an innovative glioblastoma model and created the MuNSC cell line, later acquired by Applied Biological Materials Inc. Published 14 articles in JCR journals (50% as first author). Extensive experience in biomarker research, precision oncology (NSCLC), and NIH-funded Alzheimer's projects. Skilled in leading research teams, managing clinical trial samples, and contributing to translational research initiatives. Currently focused on enhancing precision oncology strategies through a European-funded postdoctoral project.
Software
BaseSpace
Torrent Suite
FASTQC
Certification
Animal experimentation training course
Timeline
M.Sc. in Clinical Trials - undefined
University of Sevilla
Current - 12.2024
Postdoctoral Associate
Department of Environmental Health Sciences, Brain, Behavior and Environment Laboratory
08.2022 - 08.2023
Researcher Specialist I
Center of Health Research Institute of Santiago de Compostela (IDIS), Inflammation-Cardiology Area
01.2019 - 06.2022
Ph.D. in Molecular Medicine -
University of Santiago de Compostela
03.2017 - 06.2022
M.Sc. in Microbiology Research - undefined
University of Granada
09.2010 - 06.2011
B.Sc. in Molecular Biology - undefined
University of Granada
09.2002 - 06.2009
Genetic Analyst - Clinical Laboratory Assistant
Anatomical Pathology Laboratory
8 2022 - Current
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