Nuno Coelho
Senior Researcher/Consultant
Barcelona
Summary
Multidisciplinary scientist with hands-on experience in translating scientific knowledge into cutting-edge technological platforms that accelerate drug discovery. Expertise in mechanisms of collagen remodeling in fibrosis and cancer. Experienced leader with strong background in guiding teams, managing projects and archiving strategic objectives.
Overview
18
18
years of professional experience
12
12
years of post-secondary education
3
3
Languages
Work History
Senior Researcher, Biomaterials for Regenerative Therapies
Institute for Bioengineering of Catalonia
09.2022 - Current
- Overseeing laboratory operations, writing grants, mentoring trainees and managing technology transfer activities.
- Recreating stromal and immune microenvironments in organoid platforms towards personalized cancer treatment.
- Leading 2 master service agreements with Alentis Therapeutics Inc and Fibrocor Therapeutics Inc.
Consultant, Fibrosis Drug Development
Fibrocor Therapeutics Inc.
08.2022 - Current
- Assisting candidate drug program through preclinical stage
- Representing company in scientific meetings
Scientist, Drug Development
Fibrocor Therapeutics Inc.
11.2020 - 07.2022
- Acquired valuable industry experience in fast-paced matrix environment.
- Directed all operations of Fibrocor laboratory.
- Co-led monoclonal antibody antagonist program from discovery to IND enabling , collaborating with Fibrocor's in vivo team and external CRO partners.
- Coordinated development of in vitro screening and phenotypic assays to identify antibody candidates for in vivo testing: BLM model for pulmonary fibrosis, CCL4 model for liver fibrosis, and tumor xenografts.
- Managed meetings and work packages with internal teams and external partners to ensure coordination and program progress.
- Developed PK assays for analyzing samples from different animal models.
- Coordinated molecular optimization and stable pool generation of lead candidates with partner CMO.
- Designed screening and target engagement assays for selecting small molecule drug candidates in other company programs.
Postdoctoral Fellow
University of Toronto
01.2013 - 01.2020
- Investigated cellular mechanisms involved in modifying extracellular environments to maintain or restore homeostasis, with focus on Discoidin Domain Receptor 1 (DDR1) role in mechanical remodeling of collagen driven by traction forces
- This work shed light on abnormal DDR1 expression observed in various cancer and fibrotic pathologies, leading to publication of 15 peer-reviewed articles
- Established independent research program under guidance of Dr. McCulloch, renowned figure in extracellular matrix remodeling and signaling.
- Developed innovative tools to probe fundamental mechanisms underlying DDR1 moa.
- Pioneered methods for identifying and quantifying malignant characteristics in cell cultures and tissues through analysis of collagen mechanical remodeling.
- Facilitated collaboration with biotech company Galapagos, leveraging our techniques to screen their novel drug candidates.
Ph.D. Student
Institute for Bioengineering of Catalonia
04.2007 - 05.2012
- Investigated role of type IV collagen, crucial structural element of basement membrane, in modulating cell responses at biomaterial interface.
- Employed chemically modified surfaces, atomic force microscopy, and foundational cell biology techniques to investigate potential use of type IV collagen in designing biomimetic interfaces that enhance endothelialization and vascularization of implants.
- Published 4 first-author papers in reputable journals and 1 book chapter showcasing expertise at intersection of biomaterials, cell biology, and bioengineering.
Education
Ph.D. - Biomedical Engineering
Universitat Politècnica De Catalunya
Barcelona 04.2007 - 05.2012
Bachelor of Science - Biotechnology Engineering
Lusofona University
Lisboa 09.1999 - 12.2006
Skills
Project Management
Project Leadership
Advanced Data Analysis
Experimental design
Strong Work Ethic
Critical Thinking
Team Collaboration
Effective Multitasking
Delivering Presentations
Cross-Functional Teamwork
Methodology Selection
Discovery
Researchactivities
- 21 peer reviewed publications in reputable journal
- Co-inventor in 1 provisional U.S. patent
- 18 times participated as abstract selected or invited speaker at international meetings
- 14 times presented research as abstract selected poster at international meetings.
- Key studies on mechanotransduction, collagen mechanical remodeling, and DDR1 moa in fibrosis and cancer.
Teachingactivities - Experience
- Experience in teaching at the graduate level in musculoskeletal science and biology of connective tissues.
- Ability to train and mentor trainees at various levels: Postdoctoral fellows; PhD Students, Ms Students, Research assistants, and undergraduates.
Activities
Extensive involvement in professional activities, collaborations with key opinion leaders, memberships in relevant societies, and contributions as a peer reviewer for esteemed journals.
Timeline
Senior Researcher, Biomaterials for Regenerative Therapies
Institute for Bioengineering of Catalonia
09.2022 - Current
Consultant, Fibrosis Drug Development
Fibrocor Therapeutics Inc.
08.2022 - Current
Scientist, Drug Development
Fibrocor Therapeutics Inc.
11.2020 - 07.2022
Postdoctoral Fellow
University of Toronto
01.2013 - 01.2020
Ph.D. Student
Institute for Bioengineering of Catalonia
04.2007 - 05.2012
Ph.D. - Biomedical Engineering
Universitat Politècnica De Catalunya
04.2007 - 05.2012
Bachelor of Science - Biotechnology Engineering
Lusofona University
09.1999 - 12.2006
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