Highly skilled R&D Scientist with professional international experience in medicinal organic and peptide chemistry. Demonstrated track record of success, creativity, and research productivity with multiple peer-reviewed publications and scientific awards. Possesses broad scientific background in design, synthesis, purification, and characterization of small organic/medicinal molecules, amino acids building blocks, and peptides modalities. Profound theoretical knowledge about ADCs and oligonucleotides, along with expertise in executing organic chemical synthesis projects. Strong documentation and reporting skills for drug products, as well as project management abilities. Excellent communication skills and a self-motivated team player with a good sense of humor. Goal-oriented work ethic and can-do attitude, always ready to assist where needed. Passionate about utilizing science to enhance human health and contribute to company's success.
Currently, my work focuses on the medicinal chemistry synthesis of high qualify antimalarial hits for promising malaria target enzymes at a leading biopharmaceutical GSK in collaboration with the scientists at UCSD and Harvard in the US.
PI from GSK: Dr Felix Calderon
PI from UCSD: Prof Elizabeth Winzeler
Thesis title: Investigation of Methylation Catalysis of Unnatural Histone Peptides by Histone Lysine Methyltransferases (Collaboration with CRO Symeres B.V.) Chemical epigenetics in cancer disease
Promotor: Prof Floris P J T Rutjes (Radboud University)
Co-promotor: Prof Jasmin Mecinović (University of Southern Denmark, Denmark)
Collaboration between the synthetic organic chemistry group at Radboud University and Okklo Life Sciences BV
Project based on the design and synthesis of a novel cyclodextrin-linker peptide aiming for drug delivery
- Al Temimi et al. Communications Chemistry- Nature, 2019, 2, 112, https://www.nature.com/articles/s42004-019-0210-8,
- Al Temimi et al. Org. Lett., 2017, 19, 2, 400-403, https://pubs.acs.org/doi/abs/10.1021/acs.orglett.6b03608
- Al Temimi et al. Bioconjugate. Chem., 2017, 28, 8, 2160-2166, https://pubs.acs.org/doi/abs/10.1021/acs.bioconjchem.7b00319
- Al Temimi et al. Chem. Commun., 2020, 56, 3039-3042, https://pubs.rsc.org/en/content/articlehtml/2020/cc/c9cc09098c
- Al Temimi et al. Sci. Rep., 2020, 10, 21574, https://www.nature.com/articles/s41598-020-78331-0