Summary
Overview
Work History
Education
Skills
Accomplishments
Research
Dateofbirth
Personal Information
Publications
References
Hobbies and Interests
Languages
Timeline
Generic
Abbas Al Temimi

Abbas Al Temimi

Tres Cantos

Summary

Highly skilled R&D Scientist with professional international experience in medicinal organic and peptide chemistry. Demonstrated track record of success, creativity, and research productivity with multiple peer-reviewed publications and scientific awards. Possesses broad scientific background in design, synthesis, purification, and characterization of small organic/medicinal molecules, amino acids building blocks, and peptides modalities. Profound theoretical knowledge about ADCs and oligonucleotides, along with expertise in executing organic chemical synthesis projects. Strong documentation and reporting skills for drug products, as well as project management abilities. Excellent communication skills and a self-motivated team player with a good sense of humor. Goal-oriented work ethic and can-do attitude, always ready to assist where needed. Passionate about utilizing science to enhance human health and contribute to company's success.

Overview

21
21
years of professional experience

Work History

Scientist Medicinal Chemist

GSK
01.2022 - Current

Currently, my work focuses on the medicinal chemistry synthesis of high qualify antimalarial hits for promising malaria target enzymes at a leading biopharmaceutical GSK in collaboration with the scientists at UCSD and Harvard in the US.

PI from GSK: Dr Felix Calderon

PI from UCSD: Prof Elizabeth Winzeler

R&D PhD Researcher

Radboud University
06.2015 - 09.2020

Thesis title: Investigation of Methylation Catalysis of Unnatural Histone Peptides by Histone Lysine Methyltransferases (Collaboration with CRO Symeres B.V.) Chemical epigenetics in cancer disease

Promotor: Prof Floris P J T Rutjes (Radboud University)

Co-promotor: Prof Jasmin Mecinović (University of Southern Denmark, Denmark)

Synthetic Organic Chemist (Trainee)

Symeres B.V.
10.2018 - 12.2018
  • Project based on the synthesis of geometrically constrained lysine-based building blocks that were incorporated into histone peptides, and evaluated for methylation catalysis and binding

Research Scientist Organic Chemist

Okklo Life Sciences B.V.
06.2014 - 05.2015

Collaboration between the synthetic organic chemistry group at Radboud University and Okklo Life Sciences BV

Project based on the design and synthesis of a novel cyclodextrin-linker peptide aiming for drug delivery

Student Assistant/Medicinal chemistry & Chemical Biology

Utrecht University
02.2010 - 03.2011

Practicum Assistant/Assistant lecturer at Organic Chemistry lab

Al-Mustansiriyah University
08.2003 - 09.2007

Education

Ph.D. - Organic/Medicinal/Peptides Chemistry

Radboud University
Nijmegen - The Netherlands
06.2020

Master of Science - Chemical Sciences, Specialization in Drug Innovation

Utrecht University
Utrecht, The Netherlands
02.2014

Bachelor of Science - Chemistry

Utrecht University
Utrecht, The Netherlands
07.2011

BSc Science - Chemistry

Al-Mustansiriyah University
Baghdad, Iraq
08.2003

Skills

  • Highly skilled organic/medicinal/peptide scientist expertise chemist with exceptional organization skills, strong interpersonal communication ability
  • Dedicated professional ensures that all safety protocols and laboratory work atmosphere are adhered to in meeting the high standards
  • Synthetic organic chemistry, multi-step synthesis, organic synthetic strategies, troubleshooting reaction sequences, SAR library
  • Medicinal chemistry
  • ADCs knowledge
  • Oligonucleotides Knowledge
  • Peptide modalities, solid-phase peptide synthesis (SPPS), synthesis of Fmoc-protected amino acids
  • Documentation of pharmaceutical drug products
  • R&D
  • Analytical techniques, NMR, LC-MS, HPLC, MALDI-TOF MS
  • Purification methods, flash chromatography(Biotage), HPLC, crystallization, trituration
  • Project management
  • Supervision and mentoring
  • Scientific publication writing
  • Oral presentations
  • Collaboration
  • Communication
  • Teamwork
  • Cultural diversity
  • Work ethics
  • Hardworking goal-oriented
  • Social and open-minded

Accomplishments

  • Tres Cantos Open Lab Foundation Recipient, GSK, 10/01/21, Tres Cantos - Madrid, Spain
  • IMM Award for the best PhD thesis in Chemistry, Radboud University, the Netherlands, 04/22/21
  • PhD degree with honors Distinction Cum Laude, Radboud University, the Netherlands, 06/19/20
  • Best Poster Award, IMM Symposium at Radboud University, 10/30/17

Research

  • Scientist Medicinal Chemist, GSK, Tres Cantos - Madrid, Spain, 01/01/22, Present, Currently, my work focuses on the medicinal chemistry synthesis of high quality antimalarial hits at a leading biopharmaceutical company GSK in collaboration with the scientists at UCSD and Harvard in the US.
  • R&D PhD Researcher - Highest Distinction Cum Laude, Radboud University, the Netherlands, 06/01/15, 09/30/20, Thesis title: Investigation of Methylation Catalysis of Unnatural Histone Peptides by Histone Lysine Methyltransferases. Chemical epigenetics in cancer disease.
  • Synthetic Organic Chemist (Trainee), Symeres B.V., the Netherlands, 10/01/18, 12/31/18, Project based on the synthesis of geometrically constrained lysine-based building blocks that were incorporated into histone peptides, and evaluated for methylation catalysis and binding.
  • Research Scientist Organic Chemist, Okklo Life Sciences B.V, Oss, the Netherlands, 06/01/14, 05/31/15, Collaboration between the synthetic organic chemistry group at Radboud University and Okklo Life Sciences BV. Project based on the design and synthesis of a novel cyclodextrin-linker peptide aiming for drug delivery.

Dateofbirth

01/01/79, Iraq

Personal Information

Nationality: Dutch/Netherlands

Publications

- Al Temimi et al. Communications Chemistry- Nature, 2019, 2, 112, https://www.nature.com/articles/s42004-019-0210-8,

- Al Temimi et al. Org. Lett., 2017, 19, 2, 400-403, https://pubs.acs.org/doi/abs/10.1021/acs.orglett.6b03608

- Al Temimi et al. Bioconjugate. Chem., 2017, 28, 8, 2160-2166, https://pubs.acs.org/doi/abs/10.1021/acs.bioconjchem.7b00319

- Al Temimi et al. Chem. Commun., 2020, 56, 3039-3042, https://pubs.rsc.org/en/content/articlehtml/2020/cc/c9cc09098c

- Al Temimi et al. Sci. Rep., 2020, 10, 21574, https://www.nature.com/articles/s41598-020-78331-0

References

  • Prof. dr. Floris P. J. T. Rutjes, floris.rutjes@ru.nl
  • Dr. Felix Calderon, Director of Medicinal Chemistry at ViiV Healthcare, felix.x.calderon@viivhealthcare.com
  • Dr. Jose Ignacio Martin Hernando, jose.i.martin@gsk.com
  • Prof. dr. Jasmin Mecinović, mecinovic@sdu.dk


Hobbies and Interests

  • Travelling
  • Fitness training and sport
  • Walking in nature
  • Swimming
  • Cinema
  • Socializing with friends

Languages

English
Bilingual or Proficient (C2)
Dutch
Upper intermediate (B2)
Spanish
Intermediate (B1)
Arabic
Bilingual or Proficient (C2)

Timeline

Scientist Medicinal Chemist

GSK
01.2022 - Current

Synthetic Organic Chemist (Trainee)

Symeres B.V.
10.2018 - 12.2018

R&D PhD Researcher

Radboud University
06.2015 - 09.2020

Research Scientist Organic Chemist

Okklo Life Sciences B.V.
06.2014 - 05.2015

Student Assistant/Medicinal chemistry & Chemical Biology

Utrecht University
02.2010 - 03.2011

Practicum Assistant/Assistant lecturer at Organic Chemistry lab

Al-Mustansiriyah University
08.2003 - 09.2007

Ph.D. - Organic/Medicinal/Peptides Chemistry

Radboud University

Master of Science - Chemical Sciences, Specialization in Drug Innovation

Utrecht University

Bachelor of Science - Chemistry

Utrecht University

BSc Science - Chemistry

Al-Mustansiriyah University
Abbas Al Temimi